Hi-C implementation of genome structure for in silico models of radiation-induced DNA damage.

ABSTRACT: Developments in the genome organisation field has resulted in the recent methodology to infer spatial conformations of the genome directly from experimentally measured genome contacts (Hi-C data). This provides a detailed description of both intra- and inter-chromosomal arrangements. Chromosomal intermingling is an important driver for radiation-induced DNA mis-repair. Which is a key biological endpoint of relevance to the fields of cancer therapy (radiotherapy), public health (biodosimetry) and space travel. For the first time, we leverage these methods of inferring genome organisation and couple them to nano-dosimetric radiation track structure modelling to predict quantities and distribution of DNA damage within cell-type specific geometries. These nano-dosimetric simulations are highly

SUBMITTER: Ingram SP 

PROVIDER: S-EPMC7773326 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature