Pregnancy-induced humoral sensitization overrides T cell tolerance to fetus-matched allografts in mice.

ABSTRACT: Immunological tolerance to semiallogeneic fetuses is necessary to achieving successful first pregnancy and permitting subsequent pregnancies with the same father. Paradoxically, pregnancy is an important cause of sensitization, resulting in the accelerated rejection of offspring-matched allografts. The underlying basis for divergent outcomes following reencounter of the same alloantigens on transplanted organs versus fetuses in postpartum females is incompletely understood. Using a mouse model that allows concurrent tracking of endogenous fetus-specific T and B cell responses in a single recipient, we show that semiallogeneic pregnancies simultaneously induce fetus-specific T cell tolerance and humoral sensitization. Pregnancy-induced antibodies, but not B cells, impeded transplantation to

SUBMITTER: Suah AN 

PROVIDER: S-EPMC7773355 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature