A protumorigenic secretory pathway activated by p53 deficiency in lung adenocarcinoma.
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ABSTRACT:
SUBMITTER: Tan X
PROVIDER: S-EPMC7773359 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Publications
A protumorigenic secretory pathway activated by p53 deficiency in lung adenocarcinoma.
Tan Xiaochao X Shi Lei L Banerjee Priyam P Liu Xin X Guo Hou-Fu HF Yu Jiang J Bota-Rabassedas Neus N Rodriguez B Leticia BL Gibbons Don L DL Russell William K WK Creighton Chad J CJ Kurie Jonathan M JM
The Journal of clinical investigation 20210101 1
Therapeutic strategies designed to target TP53-deficient cancer cells remain elusive. Here, we showed that TP53 loss initiated a pharmacologically actionable secretory process that drove lung adenocarcinoma (LUAD) progression. Molecular, biochemical, and cell biological studies showed that TP53 loss increased the expression of Golgi reassembly and stacking protein 55 kDa (G55), a Golgi stacking protein that maintains Golgi organelle integrity and is part of a GOLGIN45 (G45)-myosin IIA-containing ...[more]
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