Identification of human long noncoding RNAs associated with nonalcoholic fatty liver disease and metabolic homeostasis.

ABSTRACT: A growing number of long noncoding RNAs (lncRNAs) have emerged as vital metabolic regulators. However, most human lncRNAs are nonconserved and highly tissue specific, vastly limiting our ability to identify human lncRNA metabolic regulators (hLMRs). In this study, we established a pipeline to identify putative hLMRs that are metabolically sensitive, disease relevant, and population applicable. We first progressively processed multilevel human transcriptome data to select liver lncRNAs that exhibit highly dynamic expression in the general population, show differential expression in a nonalcoholic fatty liver disease (NAFLD) population, and respond to dietary intervention in a small NAFLD cohort. We then experimentally demonstrated the responsiveness of selected hepatic lncRNAs to defined me

SUBMITTER: Ruan X 

PROVIDER: S-EPMC7773374 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature