Mesenchymal Bmp3b expression maintains skeletal muscle integrity and decreases in age-related sarcopenia.

ABSTRACT: Age-related sarcopenia constitutes an important health problem associated with adverse outcomes. Sarcopenia is closely associated with fat infiltration in muscle, which is attributable to interstitial mesenchymal progenitors. Mesenchymal progenitors are nonmyogenic in nature but are required for homeostatic muscle maintenance. However, the underlying mechanism of mesenchymal progenitor-dependent muscle maintenance is not clear, nor is the precise role of mesenchymal progenitors in sarcopenia. Here, we show that mice genetically engineered to specifically deplete mesenchymal progenitors exhibited phenotypes markedly similar to sarcopenia, including muscle weakness, myofiber atrophy, alterations of fiber types, and denervation at neuromuscular junctions. Through searching for genes responsib

SUBMITTER: Uezumi A 

PROVIDER: S-EPMC7773381 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature