Joint epitope selection and spacer design for string-of-beads vaccines.

ABSTRACT:

Motivation

Conceptually, epitope-based vaccine design poses two distinct problems: (i) selecting the best epitopes to elicit the strongest possible immune response and (ii) arranging and linking them through short spacer sequences to string-of-beads vaccines, so that their recovery likelihood during antigen processing is maximized. Current state-of-the-art approaches solve this design problem sequentially. Consequently, such approaches are unable to capture the inter-dependencies between the two design steps, usually emphasizing theoretical immunogenicity over correct vaccine processing, thus resulting in vaccines with less effective immunogenicity in vivo.

Results

In this work, we present a computational approach based on linear programming, called JessEV, that solves both

SUBMITTER: Dorigatti E 

PROVIDER: S-EPMC7773482 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature