Analysis of Response Data for Assessing Treatment Effects in Comparative Clinical Studies.

ABSTRACT: In comparative studies, treatment effect is often assessed using a binary outcome that indicates response to the therapy. Commonly used summary measures for response include the cumulative and current response rates at a specific time point. The current response rate is sometimes called the probability of being in response (PBIR), which regards a patient as a responder only if they have achieved and remain in response at present. The methods used in practice for estimating these rates, however, may not be appropriate. Moreover, whereas an effective treatment is expected to achieve a rapid and sustained response, the response at a fixed time point does not provide information about the duration of response (DOR). As an alternative, a curve constructed from the current response rates over th

SUBMITTER: Huang B 

PROVIDER: S-EPMC7773521 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature