Purkinje Cell Activity Determines the Timing of Sensory-Evoked Motor Initiation.

ABSTRACT: Cerebellar neurons can signal sensory and motor events, but their role in active sensorimotor processing remains unclear. We record and manipulate Purkinje cell activity during a task that requires mice to rapidly discriminate between multisensory and unisensory stimuli before motor initiation. Neuropixels recordings show that both sensory stimuli and motor initiation are represented by short-latency simple spikes. Optogenetic manipulation of short-latency simple spikes abolishes or delays motor initiation in a rate-dependent manner, indicating a role in motor initiation and its timing. Two-photon calcium imaging reveals task-related coherence of complex spikes organized into conserved alternating parasagittal stripes. The coherence of sensory-evoked complex spikes increases with learning

SUBMITTER: Tsutsumi S 

PROVIDER: S-EPMC7773552 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature