Virucidal Action Mechanism of Alcohol and Divalent Cations Against Human Adenovirus

ABSTRACT: Hygiene and disinfection practices play an important role at preventing spread of viral infections in household, industrial and clinical settings. Although formulations based on >70% ethanol are virucidal, there is a currently a need to reformulate products with much lower alcohol concentrations. It has been reported that zinc can increase the virucidal activity of alcohols, although the reasons for such potentiation is unclear. One approach in developing virucidal formulations is to understand the mechanisms of action of active ingredients and formulation excipients. Here, we investigated the virucidal activity of alcohol (40% w/v) and zinc sulfate (0.1% w/v) combinations and their impact on a human adenovirus (HAdV) using, nucleic acid integrity assays, atomic force microscopy (AFM) and

SUBMITTER: Martin-Gonzalez N 

PROVIDER: S-EPMC7773831 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature