Enhanced gamma band mutual information is associated with impaired consciousness during temporal lobe seizures.

ABSTRACT:

Background

Epileptic seizures are characterized by aberrant synchronization. We hypothesized that higher synchronization across the seizure onset zone (SOZ) channels during a temporal lobe seizure contributes to impaired consciousness.

New method

All symmetric bivariate synchronization measures were extended to multivariate measure by a principal component analysis (PCA) based technique. A novel nonparametric method has been proposed to test the statistical significance between increased synchronization across the seizure onset zone (SOZ) channels and reduced consciousness.

Results

Increased synchronization in the gamma band towards seizure termination significantly contributes to impaired consciousness (p < 0.1). Synchronization reaches its peak in the extratemporal

SUBMITTER: Dheer P 

PROVIDER: S-EPMC7773881 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature