Urinary miRNAs as biomarkers for idiopathic osteonecrosis of femoral head: A multicentre study.

ABSTRACT:

Objectives

Urinary microRNAs (miRNAs) have shown great diagnostic and prognostic values for multiple diseases. The profile of urinary miRNAs in patients with idiopathic osteonecrosis of femoral head (ONFH) is currently unclear.

Methods

We first randomly chose ten patients with each Association Research Circulation Osseous (ARCO) stage (I, II, III and IV) and ten healthy participants from the entire cohorts for initial screening. The miRNA polymerase chain reaction (PCR) array was then performed to identify the differentially abundant miRNAs in urine of these participants. We then verified the findings in the entire cohort. Clinical features including age, gender, bone mass index (BMI), lesion size and stages were recorded. We then analysed the association between the level o

SUBMITTER: Ye Y 

PROVIDER: S-EPMC7773953 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature