Effectiveness of High-risk Human Papillomavirus Testing for Cervical Cancer Screening in China: A Multicenter, Open-label, Randomized Clinical Trial.

ABSTRACT:

Importance

Evidence is needed regarding the introduction of high-risk human papillomavirus (hrHPV) testing into China's national cervical cancer screening program.

Objective

To evaluate hrHPV testing as a new screening modality for the national program.

Design, setting, and participants

This population-based, multicenter, open-label, randomized clinical trial took place across 20 primary health care centers in urban and rural areas across China. At least 3000 women aged 35 to 64 years per site were invited to participate, for a total of 60 732 women evaluated.

Interventions

At baseline, women were randomly assigned to cytology, hrHPV testing, or visual inspection with acetic acid and Lugol iodine (VIA/VILI) (rural only). Women who tested positive for hrHPV were

SUBMITTER: Zhang J 

PROVIDER: S-EPMC7774051 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature