Cyclopenta[b]indole Derivative Inhibits Aurora B in Primary Cells.

ABSTRACT: The Aurora family of kinases is closely involved in regulating cell division. Inhibition of Aurora A and B with small molecules is currently being investigated in clinical trials for the treatment of different cancers. It has also been evaluated as a treatment option against different autoimmune diseases in preclinical studies. Here, we present a cyclopenta[b]indole derivative capable of inhibiting Aurora B selectively in kinase assays. To evaluate the Aurora B inhibition capacity of the compound, we used a kinase IC₅₀ assay as well as a suppression assay of proliferating primary cells. In addition, we examined if the cells had gained a phenotype characteristic for Aurora B inhibition after treatment with the compound. We found that the compound selectively inhibited Auro

SUBMITTER: Ekebergh A 

PROVIDER: S-EPMC7774273 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature