Relationship Between Psychosocial Distress in Pregnancy and Two Genes Associated With Human Social Interaction: A Pilot Study.

ABSTRACT:

Background

Prenatal depression, anxiety, and stress (prenatal psychosocial distress) are common, and several environmental risk factors have been implicated in their development. Variation in genes, specifically single nucleotide polymorphisms (SNPs), may explain why some women develop maternal mental health concerns while others do not.

Purpose

The purpose of this pilot study was to determine the feasibility of completing SNP analyses using whole blood collected prenatally between 2008 and 2011. We examined the association between SNPs in two genes (FKBP5 and OXTR) among women with low and high prenatal psychosocial distress.

Methods

A subset (N = 50, 25 high and 25 low prenatal psychosocial distress) of participants was selected from the All Our

SUBMITTER: Dewell S 

PROVIDER: S-EPMC7774440 | biostudies-literature | 2018 Jan-Dec

REPOSITORIES: biostudies-literature