Recovery kinetics of creatine in mild plantar flexion exercise using 3D creatine CEST imaging at 7 Tesla.

ABSTRACT:

Purpose

Two-dimensional creatine CEST (2D-CrCEST), with a slice thickness of 10-20 mm and temporal resolution (τ_Res ) of about 30 seconds, has previously been shown to capture the creatine-recovery kinetics in healthy controls and in patients with abnormal creatine-kinase kinetics following the mild plantar flexion exercise. Since the distribution of disease burden may vary across the muscle length for many musculoskeletal disorders, there is a need to increase coverage in the slice-encoding direction. Here, we demonstrate the feasibility of 3D-CrCEST with τ_Res of about 30 seconds, and propose an improved voxel-wise B1+ -calibration approach for CrCEST.

Methods

The current 7T study with enrollment of 5 volunteers involved collecting the baseline CrCEST

SUBMITTER: Kumar D 

PROVIDER: S-EPMC7774507 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature