Identification of a 9-gene prognostic signature for breast cancer.

ABSTRACT: Breast cancer (BRCA) is the most common cancer among women and is the second leading cause of cancer death in women. In this study, we developed a 9-gene prognostic signature to predict the prognosis of patients with BRCA. GSE20685, GSE42568, GSE20711, and GSE88770 were used as training sets. The Kaplan-Meier plot was constructed to assess survival differences and log-rank test was performed to evaluate the statistical significance. The overall survival (OS) of patients in the low-risk group was significantly higher than that in the high-risk group. ROC analysis indicated that this 9-gene signature shows good diagnostic efficiency both in OS and disease-free survival (DFS). The 9-gene signature was further validated through GSE16446, GSE7390, and TCGA-BRCA datasets. We also established a n

SUBMITTER: Tian Z 

PROVIDER: S-EPMC7774725 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature