MicroRNA-7a2 Regulates Prolactin in Developing Lactotrophs and Prolactinoma Cells.

ABSTRACT: Prolactin production is controlled by a complex and temporally dynamic network of factors. Despite this tightly coordinated system, pathological hyperprolactinemia is a common endocrine disorder that is often not understood, thereby highlighting the need to expand our molecular understanding of lactotroph cell regulation. MicroRNA-7 (miR-7) is the most highly expressed miRNA family in the pituitary gland and the loss of the miR-7 family member, miR-7a2, is sufficient to reduce prolactin gene expression in mice. Here, we used conditional loss-of-function and gain-of-function mouse models to characterize the function of miR-7a2 in lactotroph cells. We found that pituitary miR-7a2 expression undergoes developmental and sex hormone-dependent regulation. Unexpectedly, the loss of mir-7a2 induce

SUBMITTER: LaPierre MP 

PROVIDER: S-EPMC7774778 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature