Novel Mode of Molybdate Inhibition of Desulfovibrio vulgaris Hildenborough.

ABSTRACT: Sulfate-reducing microorganisms (SRM) are found in multiple environments and play a major role in global carbon and sulfur cycling. Because of their growth capabilities and association with metal corrosion, controlling the growth of SRM has become of increased interest. One such mechanism of control has been the use of molybdate (MoO₄ ^2-), which is thought to be a specific inhibitor of SRM. The way in which molybdate inhibits the growth of SRM has been enigmatic. It has been reported that molybdate is involved in a futile energy cycle with the sulfate-activating enzyme, sulfate adenylyl transferase (Sat), which results in loss of cellular ATP. However, we show here that a deletion of this enzyme in the model SRM, Desulfovibrio vulgaris Hildenborough, remained s

SUBMITTER: Zane GM 

PROVIDER: S-EPMC7774982 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature