Paternal metabolic and cardiovascular programming of their offspring: A systematic scoping review.

ABSTRACT:

Background

There is lots of evidence that maternal peri-gestational metabolic, genomic and environmental conditions are closely linked to metabolic and cardiovascular outcomes in their offspring later in life. Moreover, there is also lotsof evidence that underlining mechanisms, such as molecular as well as epigenetic changes may alter the intrauterine environment leading to cardio-metabolic diseases in their offspring postnatal. But, there is also increasing evidence that cardio-metabolic diseases may be closely linked to their paternal metabolic risk factors, such as obesity, Type 2 Diabetes and other risk factors.

Objective

To analyse the evidence as well as specific risk factors of paternal trans-generational programming of cardio-metabolic diseases in their offspring.

SUBMITTER: Eberle C 

PROVIDER: S-EPMC7775047 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature