Daptomycin treatment impacts resistance in off-target populations of vancomycin-resistant Enterococcus faecium.

ABSTRACT: The antimicrobial resistance crisis has persisted despite broad attempts at intervention. It has been proposed that an important driver of resistance is selection imposed on bacterial populations that are not the intended target of antimicrobial therapy. But to date, there has been limited quantitative measure of the mean and variance of resistance following antibiotic exposure. Here we focus on the important nosocomial pathogen Enterococcus faecium in a hospital system where resistance to daptomycin is evolving despite standard interventions. We hypothesized that the intravenous use of daptomycin generates off-target selection for resistance in transmissible gastrointestinal (carriage) populations of E. faecium. We performed a cohort study in which the daptomycin resistance of E. faecium

SUBMITTER: Kinnear CL 

PROVIDER: S-EPMC7775125 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature