Early T-Cell Precursor Leukemia Has a Higher Risk of Induction-Related Infection among T-Cell Acute Lymphoblastic Leukemia in Adult.

ABSTRACT:

Background

Infections are an important cause of morbidity and mortality for acute lymphoblastic leukemia (ALL). However, the reports regarding risk factors of induction-related infection are roughly unknown/limited in adult T-ALL during induction chemotherapy.

Methods

We performed a retrospective cohort study for the prevalence and risk predictors of induction-related infection among consecutive T-ALL patients (N = 97) enrolled in a PDT-ALL-LBL clinical trial. Of 97 patients with T-ALL enrolled in the trial, 46 were early T-cell precursor (ETP) ALL and 51 were non-ETP ALL.

Results

When compared with non-ETP, ETP ALL subtype was characterized with lower neutrophil count (1.35 × 10⁹/L vs. 8.7 × 10⁹/L, P < 0.001) and lower myeloid perc

SUBMITTER: Huang K 

PROVIDER: S-EPMC7775137 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature