Bacterial products in donor airways prevent the induction of lung transplant tolerance.

ABSTRACT: Although postoperative bacterial infections can trigger rejection of pulmonary allografts, the impact of bacterial colonization of donor grafts on alloimmune responses to transplanted lungs remains unknown. Here, we tested the hypothesis that bacterial products present within donor grafts at the time of implantation promote lung allograft rejection. Administration of the toll-like receptor 2 (TLR2) agonist Pam₃ Cys₄ to Balb/c wild-type grafts triggered acute cellular rejection after transplantation into B6 wild-type recipients that received perioperative costimulatory blockade. Pam₃ Cys₄ -triggered rejection was associated with an expansion of CD8⁺ T lymphocytes and CD11c⁺ CD11b^hi MHC (major histocompatibility com

SUBMITTER: Tanaka S 

PROVIDER: S-EPMC7775268 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature