PIN-like ductal carcinoma of the prostate has frequent activating RAS/RAF mutations.

ABSTRACT:

Aims

Prostatic intraepithelial neoplasia-like (PIN-like) ductal carcinoma is a rare tumour characterised by often cystically dilated glands architecturally resembling high-grade PIN, but lacking basal cells. These tumours are frequently accompanied by grade group 1 acinar cancer and behave relatively indolently. In contrast, conventional ductal adenocarcinoma of the prostate is an aggressive variant comparable to grade group 4 acinar cancer. Here, we used targeted next-generation sequencing to molecularly profile PIN-like ductal carcinoma cases at radical prostatectomy.

Methods and results

Five PIN-like ductal carcinoma samples at radical prostatectomy with sufficient tumour tissue available were analysed for genomic alterations by targeted next-generation sequencing using t

SUBMITTER: Kaur HB 

PROVIDER: S-EPMC7775281 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature