Detectable HIV RNA in late pregnancy associated with low tenofovir hair levels at time of delivery among women living with HIV in the United States.

ABSTRACT:

Objective

We evaluated peripartum tenofovir (TFV) exposure via hair measures among women living with HIV in the United States.

Design

Observational cohort study.

Methods

Hair samples were collected at or shortly after childbirth among mothers enrolled in the Surveillance Monitoring for Antiretroviral Therapy Toxicities Study of the Pediatric HIV/AIDS Cohort Study between 6/2014 and 7/2016. Among mothers receiving TFV disoproxil fumarate (TDF)-based regimens during pregnancy, TFV hair concentrations were analyzed using liquid chromatography/tandem mass spectrometry. Weight-normalized TFV concentrations were log10 transformed. Multivariable linear regression assessed correlates of TFV concentrations.

Results

Overall, 121 mothers on TDF-based antiretroviral therap

SUBMITTER: Pintye J 

PROVIDER: S-EPMC7775322 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature