Ion Binding Properties and Dynamics of the bcl-2 G-Quadruplex Using a Polarizable Force Field.

ABSTRACT: G-quadruplexes (GQs) are topologically diverse, highly thermostable noncanonical nucleic acid structures that form in guanine-rich sequences in DNA and RNA. GQs are implicated in transcriptional and translational regulation and genome maintenance, and deleterious alterations to their structures contribute to diseases such as cancer. The expression of the B-cell lymphoma 2 (Bcl-2) antiapoptotic protein, for example, is under transcriptional control of a GQ in the promoter of the bcl-2 gene. Modulation of the bcl-2 GQ by small molecules is of interest for chemotherapeutic development but doing so requires knowledge of the factors driving GQ folding and stabilization. To develop a greater understanding of the electrostatic properties of the bcl-2 promoter GQ, we performed

SUBMITTER: Ratnasinghe BD 

PROVIDER: S-EPMC7775346 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature