Multi-shot acquisitions for stimulus-evoked spinal cord BOLD fMRI.

ABSTRACT:

Purpose

To demonstrate the feasibility of 3D multi-shot magnetic resonance imaging acquisitions for stimulus-evoked blood oxygenation level dependent (BOLD) functional magnetic resonance imaging (fMRI) in the human spinal cord in vivo.

Methods

Two fMRI studies were performed at 3T. The first study was a hypercapnic gas challenge where data were acquired from healthy volunteers using a multi-shot 3D fast field echo (FFE) sequence as well as single-shot multi-slice echo-planar imaging (EPI). In the second study, another cohort of healthy volunteers performed an upper extremity motor task while fMRI data were acquired using a 3D multi-shot acquisition.

Results

Both 2D-EPI and 3D-FFE were shown to be sensitive to BOLD signal changes in the cervical spinal cord, and had co

SUBMITTER: Barry RL 

PROVIDER: S-EPMC7775356 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature