Dysfunction of Mitochondrial Ca²⁺ Regulatory Machineries in Brain Aging and Neurodegenerative Diseases.

ABSTRACT: Calcium ions (Ca²⁺) play critical roles in neuronal processes, such as signaling pathway activation, transcriptional regulation, and synaptic transmission initiation. Therefore, the regulation of Ca²⁺ homeostasis is one of the most important processes underlying the basic cellular viability and function of the neuron. Multiple components, including intracellular organelles and plasma membrane Ca²⁺-ATPase, are involved in neuronal Ca²⁺ control, and recent studies have focused on investigating the roles of mitochondria in synaptic function. Numerous mitochondrial Ca²⁺ regulatory proteins have been identified in the past decade, with studies demonstrating the tissue- or cell-type-specific function of each component. The mitochondrial calc

SUBMITTER: Jung H 

PROVIDER: S-EPMC7775422 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature