The Role of CaMKII Overexpression and Oxidation in Atrial Fibrillation-A Simulation Study.

ABSTRACT: This simulation study aims to investigate how the Calcium/calmodulin-dependent protein kinase II (CaMKII) overexpression and oxidation would influence the cardiac electrophysiological behavior and its arrhythmogenic mechanism in atria. A new-built CaMKII oxidation module and a refitted CaMKII overexpression module were integrated into a mouse atrial cell model for analyzing cardiac electrophysiological variations in action potential (AP) characteristics and intracellular Ca²⁺ cycling under different conditions. Simulation results showed that CaMKII overexpression significantly increased the phosphorylation level of its downstream target proteins, resulting in prolonged AP and smaller calcium transient amplitude, and impaired the Ca²⁺ cycling stability. These effects w

SUBMITTER: Wang W 

PROVIDER: S-EPMC7775483 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature