Uncovering temperature-dependent extracellular vesicle secretion in breast cancer.

ABSTRACT: In all living things, temperature is a key factor to maintain function and survive. Animals and plants need to adapt temperature change with optimizing their behaviour and growth by sensing temperature. Similarly, tumour cells must adapt continuously to fluctuations in external conditions including temperature. To find a better environment, cancer cells promote growth and metastasis, which contributes to tumour malignancy. Pathological studies in breast cancer have implied that temperature is associated with disease progression. However, no clear mechanisms have emerged for how thermal changes affect tumour cells and their gene regulation in tumour development and malignancy. Here we discovered the temperature-dependent extracellular vesicle (EV) secretion in breast cancer. Cancer cell gro

SUBMITTER: Otsuka K 

PROVIDER: S-EPMC7775566 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature