Dysregulation of the interleukin-17A pathway in endometrial tissue from women with unexplained infertility affects pregnancy outcome following assisted reproductive treatment.

ABSTRACT:

Study question

Which transcriptomic alterations in mid-luteal endometrial scratch biopsies, taken prior to the assisted reproductive treatment (ART) treatment cycle are associated with unsuccessful pregnancy?

Summary answer

Dysregulated interleukin-17 (IL-17) pathway components are demonstrated in women who fail to become pregnant after ART.

What is known already

Implantation failure is now recognised as a critical factor in unexplained infertility and may be an important component of failed ART.

Study design, size, duration

Using a prospective longitudinal study design, 29 nulliparous women with unexplained infertility undergoing ART were recruited between October 2016 and February 2018. Mid-luteal stage endometrium and matched serum samples were collected, an

SUBMITTER: Crosby DA 

PROVIDER: S-EPMC7775620 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature