Ontology highlight
ABSTRACT:
SUBMITTER: Prola A
PROVIDER: S-EPMC7775760 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Science advances 20210101 1
Unbalanced energy partitioning participates in the rise of obesity, a major public health concern in many countries. Increasing basal energy expenditure has been proposed as a strategy to fight obesity yet raises efficiency and safety concerns. Here, we show that mice deficient for a muscle-specific enzyme of very-long-chain fatty acid synthesis display increased basal energy expenditure and protection against high-fat diet-induced obesity. Mechanistically, muscle-specific modulation of the very ...[more]