Hippocampal subfield volumetry from structural isotropic 1 mm³ MRI scans: A note of caution.

ABSTRACT: Spurred by availability of automatic segmentation software, in vivo MRI investigations of human hippocampal subfield volumes have proliferated in the recent years. However, a majority of these studies apply automatic segmentation to MRI scans with approximately 1 × 1 × 1 mm³ resolution, a resolution at which the internal structure of the hippocampus can rarely be visualized. Many of these studies have reported contradictory and often neurobiologically surprising results pertaining to the involvement of hippocampal subfields in normal brain function, aging, and disease. In this commentary, we first outline our concerns regarding the utility and validity of subfield segmentation on 1 × 1 × 1 mm³ MRI for volumetric studies, regardless of how images are segmented (i.e., m

SUBMITTER: Wisse LEM 

PROVIDER: S-EPMC7775994 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature