Atypical measures of diffusion at the gray-white matter boundary in autism spectrum disorder in adulthood.

ABSTRACT: Autism spectrum disorder (ASD) is a highly complex neurodevelopmental condition that is accompanied by neuroanatomical differences on the macroscopic and microscopic level. Findings from histological, genetic, and more recently in vivo neuroimaging studies converge in suggesting that neuroanatomical abnormalities, specifically around the gray-white matter (GWM) boundary, represent a crucial feature of ASD. However, no research has yet characterized the GWM boundary in ASD based on measures of diffusion. Here, we registered diffusion tensor imaging data to the structural T1-weighted images of 92 adults with ASD and 92 matched neurotypical controls in order to examine between-group differences and group-by-sex interactions in fractional anisotropy and mean diffusivity sampled at the GWM boun

SUBMITTER: Bletsch A 

PROVIDER: S-EPMC7775996 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature