Dataset Information

Differential serological and neutralizing antibody dynamics after an infection by a single SARS-CoV-2 strain.

ABSTRACT:

Background

We report here the case of two coworkers infected by the same SARS-CoV-2 strain, presenting two different immunological outcomes.

Case

One patient presented a strong IgG anti-receptor-binding domain immune response correlated with a low and rapidly decreasing titer of neutralizing antibodies. The other patient had a similar strong IgG anti-receptor-binding domain immune response but high neutralizing antibody titers.

Discussion and conclusion

Thus, host individual factors may be the main drivers of the immune response varying with age and clinical severity.

SUBMITTER: Billon-Denis E

PROVIDER: S-EPMC7776280 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature

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Publications

Differential serological and neutralizing antibody dynamics after an infection by a single SARS-CoV-2 strain.

Billon-Denis Emmanuelle E Ferrier-Rembert Audrey A Garnier Annabelle A Cheutin Laurence L Vigne Clarisse C Tessier Emilie E Denis Jessica J Badaut Cyril C Rougeaux Clémence C Depeille Wuille Anne A Timera Hawa H Boutin Laet Itia LI Drouet Isabelle I Verguet Noémie N Nolent Flora F Gorgé Olivier O Ferraris Olivier O Tournier Jean-Nicolas JN

Infection 20210102 4

<h4>Background</h4>We report here the case of two coworkers infected by the same SARS-CoV-2 strain, presenting two different immunological outcomes.<h4>Case</h4>One patient presented a strong IgG anti-receptor-binding domain immune response correlated with a low and rapidly decreasing titer of neutralizing antibodies. The other patient had a similar strong IgG anti-receptor-binding domain immune response but high neutralizing antibody titers.<h4>Discussion and conclusion</h4>Thus, host individua ...[more]

PMID: 33387262

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Project description:The COVID-19 antibody test was developed to investigate the humoral immune response to SARS-CoV-2 infection. In this study, we examined whether S antibody titers measured using the anti-SARS-CoV-2 IgG II Quant assay (S-IgG), a high-throughput test method, reflects the neutralizing capacity acquired after SARS-CoV-2 infection or vaccination. To assess the antibody dynamics and neutralizing potency, we utilized a total of 457 serum samples from 253 individuals: 325 samples from 128 COVID-19 patients including 136 samples from 29 severe/critical cases (Group S), 155 samples from 71 mild/moderate cases (Group M), and 132 samples from 132 health care workers (HCWs) who have received 2 doses of the BNT162b2 vaccinations. The authentic virus neutralization assay, the surrogate virus neutralizing antibody test (sVNT), and the Anti-N SARS-CoV-2 IgG assay (N-IgG) have been performed along with the S-IgG. The S-IgG correlated well with the neutralizing activity detected by the authentic virus neutralization assay (0.8904. of Spearman's rho value, p < 0.0001) and sVNT (0.9206. of Spearman's rho value, p < 0.0001). However, 4 samples (2.3%) of S-IgG and 8 samples (4.5%) of sVNT were inconsistent with negative results for neutralizing activity of the authentic virus neutralization assay. The kinetics of the SARS-CoV-2 neutralizing antibodies and anti-S IgG in severe cases were faster than the mild cases. All the HCWs elicited anti-S IgG titer after the second vaccination. However, the HCWs with history of COVID-19 or positive N-IgG elicited higher anti-S IgG titers than those who did not have it previously. Furthermore, it is difficult to predict the risk of breakthrough infection from anti-S IgG or sVNT antibody titers in HCWs after the second vaccination. Our data shows that the use of anti-S IgG titers as direct quantitative markers of neutralizing capacity is limited. Thus, antibody tests should be carefully interpreted when used as serological markers for diagnosis, treatment, and prophylaxis of COVID-19.

Dataset Information

Differential serological and neutralizing antibody dynamics after an infection by a single SARS-CoV-2 strain.

Background

Case

Discussion and conclusion

Publications

Differential serological and neutralizing antibody dynamics after an infection by a single SARS-CoV-2 strain.

Similar Datasets

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