The interesting relationship between APOBEC3 deoxycytidine deaminases and cancer: a long road ahead.

ABSTRACT: Cancer is considered a group of diseases characterized by uncontrolled growth and spread of abnormal cells and is propelled by somatic mutations. Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3 (APOBEC3) family of enzymes are endogenous sources of somatic mutations found in multiple human cancers. While these enzymes normally act as an intrinsic immune defence against viruses, they can also catalyse 'off-target' cytidine deamination in genomic single-stranded DNA intermediates. The deamination of cytosine forms uracil, which is promutagenic in DNA. Key factors to trigger the APOBEC 'off-target' activity are overexpression in a non-normal cell type, nuclear localization and replication stress. The resulting uracil-induced mutations contribute to genomic variation, which ma

SUBMITTER: Granadillo Rodriguez M 

PROVIDER: S-EPMC7776566 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature