Ontology highlight
ABSTRACT:
SUBMITTER: Alexandris N
PROVIDER: S-EPMC7776751 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Alexandris Nikolaos N Lagoumintzis George G Chasapis Christos T CT Leonidas Demetres D DD Papadopoulos Georgios E GE Tzartos Socrates J SJ Tsatsakis Aristidis A Eliopoulos Elias E Poulas Konstantinos K Farsalinos Konstantinos K
Toxicology reports 20201219
SARS-CoV-2 infection was announced as a pandemic in March 2020. Since then, several scientists have focused on the low prevalence of smokers among hospitalized COVID-19 patients. These findings led to our hypothesis that the Nicotinic Cholinergic System (NCS) plays a crucial role in the manifestation of COVID-19 and its severe symptoms. Molecular modeling revealed that the SARS-CoV-2 Spike glycoprotein might bind to nicotinic acetylcholine receptors (nAChRs) through a cryptic epitope homologous ...[more]