Machine-learning-driven biomarker discovery for the discrimination between allergic and irritant contact dermatitis.

ABSTRACT: Contact dermatitis tremendously impacts the quality of life of suffering patients. Currently, diagnostic regimes rely on allergy testing, exposure specification, and follow-up visits; however, distinguishing the clinical phenotype of irritant and allergic contact dermatitis remains challenging. Employing integrative transcriptomic analysis and machine-learning approaches, we aimed to decipher disease-related signature genes to find suitable sets of biomarkers. A total of 89 positive patch-test reaction biopsies against four contact allergens and two irritants were analyzed via microarray. Coexpression network analysis and Random Forest classification were used to discover potential biomarkers and selected biomarker models were validated in an independent patient group. Differential gene-ex

SUBMITTER: Fortino V 

PROVIDER: S-EPMC7776829 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature