Genetic sexing strains for the population suppression of the mosquito vector Aedes aegypti.

ABSTRACT: Aedes aegypti is the primary vector of arthropod-borne viruses including dengue, chikungunya and Zika. Vector population control methods are reviving to impede disease transmission. An efficient sex separation for male-only releases is crucial for area-wide mosquito population suppression strategies. Here, we report on the construction of two genetic sexing strains using red- and white-eye colour mutations as selectable markers. Quality control analysis showed that the Red-eye genetic sexing strains (GSS) is better and more genetically stable than the White-eye GSS. The introduction of an irradiation-induced inversion (Inv35) increases genetic stability and reduces the probability of female contamination of the male release batches. Bi-weekly releases of irradiated males of both the

SUBMITTER: Koskinioti P 

PROVIDER: S-EPMC7776939 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature