An in vivo atlas of host-pathogen transcriptomes during Streptococcus pneumoniae colonization and disease.

ABSTRACT: Streptococcus pneumoniae (Spn) colonizes the nasopharynx and can cause pneumonia. From the lungs it spreads to the bloodstream and causes organ damage. We characterized the in vivo Spn and mouse transcriptomes within the nasopharynx, lungs, blood, heart, and kidneys using three Spn strains. We identified Spn genes highly expressed at all anatomical sites and in an organ-specific manner; highly expressed genes were shown to have vital roles with knockout mutants. The in vivo bacterial transcriptome during colonization/disease was distinct from previously reported in vitro transcriptomes. Distinct Spn and host gene-expression profiles were observed during colonization and disease states, revealing specific genes/operons whereby Spn adapts to a

SUBMITTER: D'Mello A 

PROVIDER: S-EPMC7777036 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature