Synaptic plasticity rules with physiological calcium levels.

ABSTRACT: Spike-timing-dependent plasticity (STDP) is considered as a primary mechanism underlying formation of new memories during learning. Despite the growing interest in activity-dependent plasticity, it is still unclear whether synaptic plasticity rules inferred from in vitro experiments are correct in physiological conditions. The abnormally high calcium concentration used in in vitro studies of STDP suggests that in vivo plasticity rules may differ significantly from in vitro experiments, especially since STDP depends strongly on calcium for induction. We therefore studied here the influence of extracellular calcium on synaptic plasticity. Using a combination of experimental (patch-clamp recording and Ca²⁺ imaging at CA3-CA1 synapses) and theoretical approaches, we show here that t

SUBMITTER: Inglebert Y 

PROVIDER: S-EPMC7777146 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature