Body mass index and height and risk of cutaneous melanoma: Mendelian randomization analyses.

ABSTRACT:

Background

Height and body mass index (BMI) have both been positively associated with melanoma risk, although findings for BMI have been less consistent than height. It remains unclear, however, whether these associations reflect causality or are due to residual confounding by environmental and lifestyle risk factors. We re-evaluated these associations using a two-sample Mendelian randomization (MR) approach.

Methods

We identified single nucleotide polymorphisms (SNPs) for BMI and height from separate genome-wide association study (GWAS) meta-analyses. We obtained melanoma SNPs from the most recent melanoma GWAS meta-analysis comprising 12 874 cases and 23 203 controls. We used the inverse variance-weighted estimator to derive separate causal risk estimates across all SNP in

SUBMITTER: Dusingize JC 

PROVIDER: S-EPMC7778056 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature