High-resolution imaging reveals microbial biofilms on patient urinary catheters despite antibiotic administration.

ABSTRACT:

Purpose

Catheter-associated urinary tract infections (CAUTIs) are a significant cause of morbidity worldwide, as they account for 40% of all hospital-associated infections. Microbial biofilm formation on urinary catheters (UCs) limits antibiotic efficacy, making CAUTI extremely difficult to treat. To gain insight into the spatiotemporal microbe interactions on the catheter surface we sought to determine how the presence or absence of bacteriuria prior to catheterization affects the organism that ultimately forms a biofilm on the UC and how long after catheterization they emerge.

Methods

Thirty UCs were collected from patients who received a urine culture prior to catheterization, a UC, and antibiotics as part of standard of care. Immunofluorescence imaging and scanning elect

SUBMITTER: Walker JN 

PROVIDER: S-EPMC7778452 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature