The Effect of Goal-Directed Therapy on Patient Morbidity and Mortality After Traumatic Brain Injury: Results From the Progesterone for the Treatment of Traumatic Brain Injury III Clinical Trial.

ABSTRACT:

Objectives

To estimate the impact of goal-directed therapy on outcome after traumatic brain injury, our team applied goal-directed therapy to standardize care in patients with moderate to severe traumatic brain injury, who were enrolled in a large multicenter clinical trial.

Design

Planned secondary analysis of data from Progesterone for the Treatment of Traumatic Brain Injury III, a large, prospective, multicenter clinical trial.

Setting

Forty-two trauma centers within the Neurologic Emergencies Treatment Trials network.

Patients

Eight-hundred eighty-two patients were enrolled within 4 hours of injury after nonpenetrating traumatic brain injury characterized by Glasgow Coma Scale score of 4-12.

Measurements and main results

Physiologic goals were define

SUBMITTER: Merck LH 

PROVIDER: S-EPMC7778459 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature