New novel non-MHC genes were identified for cervical cancer with an integrative analysis approach of transcriptome-wide association study.

ABSTRACT: Although genome-wide association studies (GWAS) have successfully identified multiple genetic variants associated with cervical cancer, the functional role of those variants is not well understood. To bridge such gap, we integrated the largest cervical cancer GWAS (N = 9,347) with gene expression measured in six human tissues to perform a multi-tissue transcriptome-wide association study (TWAS). We identified a total of 20 associated genes in the European population, especially four novel non-MHC genes (i.e. WDR19, RP11-384K6.2, RP11-384K6.6 and ITSN1). Further, we attempted to validate our results in another independent cervical cancer GWAS from the East Asian population (N = 3,314) and re-discovered four genes including WDR19, HLA-DOB</

SUBMITTER: Chen H 

PROVIDER: S-EPMC7778537 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature