Decoding Immune Heterogeneity of Melanoma and identifying immune-prognostic hub genes.

ABSTRACT: Melanoma is an aggressive skin cancer that has gained attention worldwide. Growing evidence has highlighted that the tumor microenvironment (TME) is an important feature of carcinogenesis and contributes to therapeutic efficacy in melanoma. However, additional advances in melanoma immuno-oncology are necessary to achieve a comprehensive knowledge of the immune infiltrate population and to identify accurate and readily measurable biomarkers. In this study, we analyzed gene expression of 468 melanoma cases from the TCGA database, which led to the identification of three melanoma clusters (representedby low, median and high infiltration) that display unique immune features. We found that the microenvironment clusters had substantial prognostic efficacy. The median cluster was characterized by

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC7778557 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature