Chemo-informatics guided study of natural inhibitors targeting rho GTPase: a lead for treatment of glaucoma.

ABSTRACT: Glaucoma, the most perilous disease leading to blindness is a result of optical neuropathy. Accumulation of aqueous humor in the posterior chamber due to a large difference in the rate of formation and its drainage in the anterior chamber causes an increase in intraocular pressure (IOP) leading to damage of nerve cells. A literature survey has revealed that inhibition of the Rho guanosine triphosphatases (rho GTPase) pathway by specific inhibitors leads to the relaxation of contractile cells involved in the aqueous outflow pathway. Relaxation of the strained contractile cells results in increased outflow thereby releasing IOP. In the present study molecular docking has been used to screen twenty seven bioactive (17 natural compounds and 10 conventional drugs) compounds that may play a sign

SUBMITTER: Rai SK 

PROVIDER: S-EPMC7778655 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature