In silico analysis of phytoconstituents from Tinospora cordifolia with targets related to diabetes and obesity.

ABSTRACT: Traditionally, Tinospora cordifolia is commonly used in the treatment of diabetes and obesity; has been evaluated for their anti-diabetic and anti-obese potency in experimental animal models. However, the binding affinity of multiple bioactives with various proteins involved in the pathogenesis of diabetes and obesity has not been reported yet. Hence, the present study aimed to assess the binding affinity of multiple bioactives from T. cordifolia with various targets involved in the pathogenesis of diabetes and obesity. The ligands and targets were retrieved from the PubChem and Protein Data Bank respectively and docked using autodock4.0. Druglikeness and absorption, distribution, metabolism, excretion, and toxicity profile were predicted using Molsoft and admetSAR1 respectiv

SUBMITTER: Mandar BK 

PROVIDER: S-EPMC7778662 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature