Age differences in predicting working memory performance from network-based functional connectivity.

ABSTRACT: Deterioration in working memory capacity (WMC) has been associated with normal aging, but it remains unknown how age affects the relationship between WMC and connectivity within functional brain networks. We therefore examined the predictability of WMC from fMRI-based resting-state functional connectivity (RSFC) within eight meta-analytically defined functional brain networks and the connectome in young and old adults using relevance vector machine in a robust cross-validation scheme. Particular brain networks have been associated with mental functions linked to WMC to a varying degree and are associated with age-related differences in performance. Comparing prediction performance between the young and old sample revealed age-specific effects: In young adults, we found a general unpredicta

SUBMITTER: Plaschke RN 

PROVIDER: S-EPMC7778730 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature