Heterotopic ossification in lymph node metastasis after rectal cancer resection: a case report and literature review.

ABSTRACT:

Background

Heterotopic ossification (HO) is the formation of osseous tissue outside the skeleton. HO in malignant tumors of the digestive tract is extremely rare, as is ossification in metastatic lesions from HO-negative digestive tract tumors. Regarding the pathogenesis of HO, two theories have been proposed. The first is that the osteoblastic metaplasia of tumor cells (driven by the epithelial-mesenchymal transition, EMT) results in HO, and the second is that factors secreted by cancer cells lead to the metaplasia of stromal pluripotent cells into osteoblasts. However, the osteogenic mechanisms remain unclear.

Case presentation

An 83-year-old Japanese woman underwent low anterior rectal resection for rectal cancer before presentation at our institution, in June 2018. The f

SUBMITTER: Nagano H 

PROVIDER: S-EPMC7778818 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature