PCAT: an integrated portal for genomic and preclinical testing data of pediatric cancer patient-derived xenograft models.

ABSTRACT: Although cancer is the leading cause of disease-related mortality in children, the relative rarity of pediatric cancers poses a significant challenge for developing novel therapeutics to further improve prognosis. Patient-derived xenograft (PDX) models, which are usually developed from high-risk tumors, are a useful platform to study molecular driver events, identify biomarkers and prioritize therapeutic agents. Here, we develop PDX for Childhood Cancer Therapeutics (PCAT), a new integrated portal for pediatric cancer PDX models. Distinct from previously reported PDX portals, PCAT is focused on pediatric cancer models and provides intuitive interfaces for querying and data mining. The current release comprises 324 models and their associated clinical and genomic data, including gene expres

SUBMITTER: Yang J 

PROVIDER: S-EPMC7778893 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature